Arctic peptides semaglutide reddit - But lost 10lbs and now 2 months down 15lbs.

 
Ordered <b>semaglutide</b> April 28th it Ordered <b>semaglutide</b> April 28th it arrived at my house today May 11th. . Arctic peptides semaglutide reddit

I have only used Ozempic (1mg) previously, and I’m ready for a higher dose. I have used semaglutide compounded since the start. Jul 7, 2023 · Semaglutide also moderates the production of glucose in the liver and the release of glucagon from the pancreas, leading to lower fasting and postprandial glucose levels. My physician stated semaglutide does take up to 12 weeks to fully. I am very interested in anti aging peptides- specifically sermorelin and epitalon. Everyone’s weight loss journey looks different and how much weight you have to lose will determine the duration of your program. Jul 7, 2023 · Semaglutide also moderates the production of glucose in the liver and the release of glucagon from the pancreas, leading to lower fasting and postprandial glucose levels. To keep it simple, add 3 ml of bacteriostatic water to your 3 mg bottles of Semaglutide. 25mg a week for 4 weeks and if it's not working for you, bump it up to 0. Peptides are miniscule, some are microscopic, so fillers like mannitol are added so that when you're vial arrives it doesn't look empty. Okay, so tried Semaglutide. I also used 2 vials from qsc and both strong. week 9-12 : 1mg once weekly. Some other information is missing from the certificate. Does anyone pre-fill a months worth of semaglutide injections (~4) and store in the fridge instead of filling an individual syringe every week? When researching, many compounding pharmacies send people home with a months worth of injections so I’m interested if this is a effective. Now offering Semaglutide and Tirzepatide. I'm taking 1. I’ve had increased hunger but I’m not sure if it’s due to. You do NOT want to dose high starting out even at 250mcg people have side effects and they can be very unsavory. I’ve tried to search around and find the answer on my own but. Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist that is under development for the treatment of type 2 diabetes. CAD $ 174. 0. week 9-12 : 1mg once weekly. All variations of tirzepatide and semaglutide are peptides (or technically, polypeptides). Don't like the idea, I wouldn't use it. In addition, Amazon sells STERILE bacteriostatic water for reconstitution. Zero nausea or negative GI issues. 5 mg vial, you want a dose of 1 mg in 0. I’ve ordered from them a few times and never had an issue. Shake the Sema vial (lightly) to make sure it's dissolved. Some other information is missing from the certificate. Tirzepatide is a peptide that activates both GLP-1 and GIP receptors. I have requested the testing they said they did and they have not replied. This medicine is also used together with diet and exercise to help lose weight and keep the weight off in patients with obesity caused by certain conditions. Safety of Semaglutide The glucagon-like peptide-1 receptor agonist (GLP-1RA) semaglutide is the most recently approved agent of this drug class, and the only GLP-1RA currently available as both subcutaneous and oral formulation. They accidentally sent me 4 vials instead of 5 and they sent the missing vial so quickly. I’m so glad I could get it compounded. How semaglutide has changed my life. Does anyone pre-fill a months worth of semaglutide injections (~4) and store in the fridge instead of filling an individual syringe every week? When researching, many compounding pharmacies send people home with a months worth of injections so I’m interested if this is a effective. The math I use is this: 100 ticks per 1ml syringe. 35/mg) of something (hopefully Tirzepatide) 😂 Peptide Sciences was $160/ 5mg ($32/mg; no 10mg vial available) plus 10% off. I wrote customer service to ask if there were any coupons available (stated my intention to purchase it for my wife for her birthday). I wrote customer service to ask if there were any coupons available (stated my intention to purchase it for my wife for her birthday). There are a number of communities that conduct group testing on peptides, generally through Janoshik as he's the most reliable in this sphere. Start with 0. It has the same effect in the body, however the FDA has not been asked to officially rule on. Reconstituting peptides refers to the process of dissolving or rehydrating lyophilized (freeze-dried) peptides to prepare them for use in research. I have no idea what I’m doing, I know I need to add the bac water to reconstitute the powder. Semaglutide Sellers and Syringe Storing. Question about semaglutide and sermorelin/epitalon. 5mg vials came unlabeled with pink tops. Helix Chemical Supply prices for Semaglutide, Tirzepatide w/Coupon Code. I have requested the testing they said they did and they have not replied. His practice is in Ohio. Read this article that Tirzepatide was actually more effective than Semaglutide so I decided to give it a go. First off, on their landing page they use MADE IN USA and show a pic of Semaglutide. We are a community that can openly discuss semaglutide compounds. 5mg or less I reconstitute with 1ml bac water. Incorrect. Obesity is a global health challenge with few pharmacologic options. Semaglutide-treated participants, compared with placebo, were also more likely to lose at least 10%, 15% or 20% of baseline body weight at week 104 (P < 0. Semaglutide’s latest regulatory win came in June 2021 when it won the brand name Wegovy and became the first and only prescription weight-loss. However I don’t want to reduce the effectiveness of the sema. Semaglutide is a medication that has been approved by the FDA to treat type 2 diabetes and has also been approved for obesity management under the brand name Wegovy [ 1 ] [ 3 ]. stick with arctic, peptide sciences, or wicked labz if you're ordering domestic everyone else is over priced. Both studies reported patients exhibiting. I am using it myself, but you need to ramp up slowly. Novo Nordisk holds a patent on the molecule, everyone else is selling it in violation of that patent. I’m probably going to annoy some people asking this, but I see a lot of knowledgeable people on here. Novo exclusively owns semaglutide and won its first FDA approval for the molecule in September 2019. This is why I probably won't be using it again. This is misleading as Novo Nordisk holds. Available variations: 2mg and 5mg Test Results (Updated Oct 18, 2023): 2mg batch S723D117 - Janoshik and MZ Biolabs 5mg batch S923D123 - Janoshik. Buy 1 get 3 free, code Easter. I've just done my first dosage of 20 on an insulin syringe. I complained to them and they refunded all my money. A friend purchased MK677 from Peptide Sciences and was dealing with excessive hunger. You can do 0. • 18 min. Question about long-term use. The answer is patent protection, which is another way of saying government-granted monopoly. We offer a catalog of research-grade peptides for sale to professionals in academic and industrial settings. 50 dose . Just sharing my experience. 0. 00 Add to cart Tirzepatide Sodium 11mg CAD $ 174. Semaglutide. Mar 1, 2023 · Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. This is a place to share our experiences. Sorry sorry sorry, I know there are a bazillion of these but I was wondering if someone could give me advice on dosage. BPC 157 helped me regain the ability to physically function after years of living with chronic issues including the inability to walk long distances. I recently switched from ozempic to compounded Semaglutide, the first month of switching on the same dosage I didn’t feel any difference. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. This medicine is also used together with diet and exercise to help lose weight and keep the weight off in patients with obesity caused by certain conditions. I don’t use Semaglutide but the sources are generally the same as I use for other. 50mg/week in month two. Question about long-term use. Further instructions: Start with. Can someone help me figure out how many “units” I should be taking?. Reconstituting peptides refers to the process of dissolving or rehydrating lyophilized (freeze-dried) peptides to prepare them for use in research. This is a place to share our experiences. I just had my first and certainly my LAST experience with SAF Research. I quick search I did came up with this. 5 Minpinthree • 3 mo. I am very interested in anti aging peptides- specifically sermorelin and epitalon. I see on the Arctic site they have 5mg. Shake the Sema vial (lightly) to make sure it's dissolved. Add to cart. It worked immediately, but the side effects didn't seem to subside (nausea). Finally, after years of thinking I was just destined to be overweight, I had my answer. You can discuss where you purchase products whether you are with a provider or do your own research with peptides and purchase for research purposes. I wrote customer service to ask if there were any coupons available (stated my intention to purchase it for my wife for her birthday). 5 mL of bacteriostatic water in the 5 mg vial and then dose accordingly, being careful not to use the vial longer than 2 months as that's the"best by" date for reconstituted vials. The topical GHK-CU was not needed much as the skin greatly improved and it stays that way. Dosage: Oral. The downside of long term GLP1 agonists is that they do promote 24/7 proliferation of. Does anyone have any experience with either helix or Arctic peptide and they can confirm it is legit?. Semaglutide. A lot of people also use Semaglutide which falls under Peptides but isn't really one. When you have a monopoly you can charge what the market will bear, and it’ll apparently bear $1000 pens. While nearly 62% of patients achieved 10% or more. The only FDA licensed source of semaglutide is novo nordisk. I've been in constant communication with them. Seeds doesn't sell anything. BPC 157 helped me regain the ability to physically function after years of living with chronic issues including the inability to walk long distances. View Products GUARANTEED QUALITY We stand behind all of our products with a 30-day money-back guarantee. Semaglutide from PS is real but under dosed. Has anyone tested Arctic Peptides for quality? I listened to a podcast where Dr. 5cc needle. 2 u/25orsixtofore Apr 18 '23. • 3 days ago. 0. I’ve tried to search around and find the answer on my own but. I ordered semaglutide from a peptide website and don't really think it's working. I have only used Ozempic (1mg) previously, and I’m ready for a higher dose. Newbie question. I've been in constant communication with them. What you might do is titrate up faster if your body can handle it. Many people, myself included. I've got a reliable source but might check it out. ladybugspaceship • 7 mo. 50mg/week in month two. They accidentally sent me 4 vials instead of 5 and they sent the missing vial so quickly. Chance_Pear7283 • 1 yr. Combined with training, diet, and perhaps Metformin, you can lose weight rapidly. My weight loss doctor (specialist through the hospital) found the company and uses it for other patients who are paying full price for Wegovy. Seeds talking about a lot of the online research companies having broken or incomplete peptides, which could cause unpredictable effects with extended use. Workout_mania_usa • 6 mo. 7 mg subcutaneously once a week. Semaglutide is a potent agonist of the glucagon-like peptide 1 (GLP-1) receptor, which is just a very scientific way of saying it will help increase levels of insulin. 💊 🧪 Forms: Injectable, topical, and peptide blends. CAD $ 99. A friend who knows the owner recommended them to me. 25 for a dose. Arctic Peptides provides products strictly for research and development purposes. At higher doses, it can act on centers in the brain and help suppress appetite. Just received semaglutide powder from arctic peptides in mail. 35/mg) of something (hopefully Tirzepatide) 😂 Peptide Sciences was $160/ 5mg ($32/mg; no 10mg vial available) plus 10% off. I spent three months in Singapore where I developed a skin infection that has caused me to be on antibiotics five times. 20 lbs down in 2 months. Both! I just purchased the 5mg Tirzepatide through them. I have only used Ozempic (1mg) previously, and I’m ready for a higher dose. Don't like the idea, I wouldn't use it. Does anyone pre-fill a months worth of semaglutide injections (~4) and store in the fridge instead of filling an individual syringe every week? When researching, many compounding pharmacies send people home with a months worth of injections so I’m interested if this is a effective. • 18 min. This medicine is also used together with diet and exercise to help lose weight and keep the weight off in patients with obesity caused by certain conditions. 00 Select options Tirzepatide Sodium 6mg CAD $ 100. So far it has not helped me but in a few weeks I will get to. This medicine is also used together with diet and exercise to help lose weight and keep the. by acatcatcat View community ranking In the Top 10% of largest communities on Reddit Just did my first with Arctic Peptides Did my first 1 mg dose with Arctic Peptides. These insulin syringes are considered ideal for the research peptides we carry – Semaglutide and Tirzepatide. There are people using peptide sciences and I believe they are alive so far. I am very interested in anti aging peptides- specifically sermorelin and epitalon. Everyone’s weight loss journey looks different and how much weight you have to lose will determine the duration of your program. Semaglutide Sellers and Syringe Storing. Used in conjunction with lifestyle changes and a reduced-calorie diet. While GLP-1RAs effectively improve glycemic control and cause weight loss, potential safety c. We bought both Semaglutide 89$ for 5 mg vials and tirtepezide so. The answer is patent protection, which is another way of saying government-granted monopoly. Read this article that Tirzepatide was actually more effective than Semaglutide so I decided to give it a go. I currently use Helix and have good results. The resulting drug product, sold under the brand name Rybelsus, is the. This is made up of semaglutide sodium and semaglutide acetate. With 1ml of bac water I'd take half. 4 mg. Arctic gives discounts, is reasonably priced, cares about customers and customer service. Is Arctic Peptides still selling Bac Water? Is Arctic out of the bacteriostatic water, or did they quit selling it? It was in my cart to check out and now it seems to be gone from their website. ago Dr. Mohammed Fouda. Newbie question. I'm taking 1. I've never used a peptide in my life so I have reference point other than what I have read here in this subreddit. week 13-16 : 1. This was the same arm I received the shot in. I'd use it if there were peptides other than sema/tirz. Does anyone pre-fill a months worth of semaglutide injections (~4) and store in the fridge instead of filling an individual syringe every week? When researching, many compounding pharmacies send people home with a months worth of injections so I’m interested if this is a effective. I believe the guy uses Semaglutide himself and is a genuine good person who wants to help others on the GLP1 journey. Not a sponsored post. I just sent you a pm we ship to all 50 states. Semaglutide is sourced from a single mountain spring. What I've learned over the years is that China is loyal to those who spend thousands on orders per month vs little me who spends hundreds — if that. NOConfidenceNU • 9 hr. infact even the name brand gets the bulk supply from China. Zero effects from the first vial and I don’t really want to try the second vial. I ate more than normal/. When you have a monopoly you can charge what the market will bear, and it’ll apparently bear $1000 pens. 📬 Shipping Policy: Free for $200+, Flat rate $9. You can start feeling the effects of the Semaglutide at your first dose and should start experiencing weight loss within the first two weeks of your program. We assessed the efficacy, safety, and tolerability of semaglutide monotherapy, compared with placebo, in treatment-naive patients with type 2 diabetes who had insufficient glycaemic control with diet and exercise alone. The resulting drug product, sold under the brand name Rybelsus, is the. Both studies reported patients exhibiting. I've tested ipa and cjc tho, it came back as 99% and 98% respectively. I've got a reliable source but might check it out. You should do each level 0. This is why I probably won't be using it again. My immune system is now shot and everything is going a bit haywire. Mohammed Fouda. Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist that is under development for the treatment of type 2 diabetes. For the CJC at 1mg use 2ml water and draw 40units. So far it has not helped me but in a few weeks I will get to. Not a sponsored post. Showing all 4 results Semaglutide Sodium CAD $ 60. It kills appetite without making you speedy or nauseous like stimulants or other appetite suppressants. 27. So far it has not helped me but in a few weeks I will get to the full type 2 diabetes version/dose (I am not diabetic) of 1. 3000/100*8 = 240mcg. Jul 7, 2023 · Semaglutide also moderates the production of glucose in the liver and the release of glucagon from the pancreas, leading to lower fasting and postprandial glucose levels. When you have a monopoly you can charge what the market will bear, and it’ll apparently bear $1000 pens. Within a week of switching to Arctic Peptides Semaglutide, hunger decrease dropped off substantially. Reconstitution was easy, but I am a chemical engineer, so the conversions and math are kind of second nature to me. Now offering Semaglutide and Tirzepatide. New to all this but see they are out of 10mg of tirzepatide as well ( I just ordered 5mg) sooooo- wondering what’s up?. Insert the needle into the Sema vial. I think you can keep increasing up to 2. I reached out to the laboratory that was listed on the CoA and got this response: That certificate belongs to Accelerate Labs in Florida. Add to cart. Does anyone pre-fill a months worth of semaglutide injections (~4) and store in the fridge instead of filling an individual syringe every week? When researching, many compounding pharmacies send people home with a months worth of injections so I’m interested if this is a effective. Pull your. shop/product/semaglutide-5mg/# $125 5mg https://prestigepeptides. An approved antidiabetic treatment due to its hypoglycemic effects, it is. 50mg/week like OP two bottles should last 3 months or $960/year before site discounts. I've tried two different vials and it just doesn't seem to have any effect with the exception of my stool being effected. Novo exclusively owns semaglutide and won its first FDA approval for the molecule in September 2019. It has been so helpful to me, to see the different types of experiences and side effects. I ordered semaglutide from a peptide website and don't really think it's working. GLP-1 plays a role in regulating blood sugar levels and appetite. I ordered semaglutide from a peptide website and don't really think it's working. My final dosages from the above was 1mg. I have only used Ozempic (1mg) previously, and I’m ready for a higher dose. slutbang, bokep jolbab

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110 votes, 143 comments. 25mg Enclomiphene Daily (oral tablet) 1000iu HCG weekly (2x injection) HGH FRAGMENT 176-191- plan would be to start at 300mcg a day for first week, and gradually increase my dosage each week for 6 weeks. ImpalerV • 3 mo. 5 mg vial, you want a dose of 1 mg in 0. But, Tirzepatide delivers superior results compared to Semaglutide. The easiest way is to add 2ml of bac water. I reached out to the laboratory that was listed on the CoA and got this response: That certificate belongs to Accelerate Labs in Florida. com/product/semaglutide-glp-1-analogue-5mg/ $120 5mg. I’ve used 3 vials from arctics semaglutide and 2 were super strong and 1 vial I felt nothing. I took my fourth dose Wednesday morning, upping it from 190 mcg to 250 mcg. I bought mine from Arctic Peptides (it is arriving today, yay!), and I will be starting on Friday to allow the weekend to act as a buffer for any side effects. 43 Read more Browse our product line of research peptides and lab supplies. ago I’ve used 3 vials from arctics semaglutide and 2 were super strong and 1 vial I felt nothing. 💊 🧪 Forms: Injectable, topical, and peptide blends. week 17+ 2. Semaglutide is a derivative of the naturally occurring GLP-1, a peptide known to lower blood sugar levels and enhance insulin secretion. I purchased 5mg semaglutide from Artic Peptides. Does anyone pre-fill a months worth of semaglutide injections (~4) and store in the fridge instead of filling an individual. While GLP-1RAs effectively improve glycemic control and cause weight loss, potential safety c. In January 2020, semaglutide was again approved to lower the likelihood of major adverse cardiovascular events in patients with Type 2 diabetes and is being marketed as Ozempic in this indication. 5ml or 50 units for my shots. This is why I probably won't be using it again. Here's a list I made recently https://aminoasylum. Does anyone pre-fill a months worth of semaglutide injections (~4) and store in the fridge instead of filling an individual syringe every week? When researching, many compounding pharmacies send people home with a months worth of injections so I’m interested if this is a effective. Insert the needle into the Sema vial. Novo exclusively owns semaglutide and won its first FDA approval for the molecule in September 2019. Get the Reddit app Scan this QR code to download the app now. 5mg or less I reconstitute with 1ml bac water. It helps to suppress appetite through the brain, and it slows stomach emptying to increase the sensation of fullness. Jul 7, 2023 · Semaglutide also moderates the production of glucose in the liver and the release of glucagon from the pancreas, leading to lower fasting and postprandial glucose levels. I've tried two different vials and it just doesn't seem to have any effect with the exception of my stool being effected. Read this article that Tirzepatide was actually more effective than Semaglutide so I decided to give it a go. Over 75% of the participants on semaglutide had a weight loss of 5% of baseline or more. Deb555 • 24 days ago. Now offering Semaglutide and Tirzepatide. That's helpful. This should be 25 on a. 0001 for the OR for the 10% and 15%. Newbie question. My cholesterol dropped drastically while A1C is “normal” for the first time in decades. But lost 10lbs and now 2 months down 15lbs. He is an orthopedic surgeon and prominent educator in cellular medicine. So I added 1 ml to get 0. Been dosing at 2. Read this article that Tirzepatide was actually more effective than Semaglutide so I decided to give it a go. 3mg = 3000mcg. ago I’ve used 3 vials from arctics semaglutide and 2 were super strong and 1 vial I felt nothing. This medicine is also used together with diet and exercise to help lose weight and keep the weight off in patients with obesity caused by certain conditions. This is a place to share our experiences. While the category of peptides is quite broad, here are some relevant peptides approved for human use. Ajadedepiphany • 5 mo. Semaglutide’s latest regulatory win came in June 2021 when it won the brand name Wegovy and became the first and only prescription weight-loss. All in all it made me eat less healthy. Newbie question. 25 dose once a week, my start weight was 91kgs I'm 45 years old and 1. 25mg Enclomiphene Daily (oral tablet) 1000iu HCG weekly (2x injection) HGH FRAGMENT 176-191- plan would be to start at 300mcg a day for first week, and gradually increase my dosage each week for 6 weeks. There are better companies who test every batch and will give you. Did my first 1 mg dose with Arctic Peptides. I'm down 12lbs and husband is down 16. I’m curious if anyone has any experience. I got tirzapatide and not semaglutide but it was very strong. BPC 157 helped me regain the ability to physically function after years of living with chronic issues including the inability to walk long distances. I've tried two different vials and it just doesn't seem to have any effect with the exception of my stool being effected. Now offering Semaglutide and Tirzepatide. Obesity is a global health challenge with few pharmacologic options. Additional information. 25mg twice a week works much better for me than 0. 5 ml or 50 units). week 5-8 : 0. 50 dose . SAF, now known as RCS Research — flat out told me they refused to test with an independent lab because they don't believe in it. That's helpful. Semaglutide’s latest regulatory win came in June 2021 when it won the brand name Wegovy and became the first and only prescription weight-loss. CAD $ 99. BPC 157 helped me regain the ability to physically function after years of living with chronic issues including the inability to walk long distances. 1,20,21,27 In the. Newbie question. I feel I must describe my experience, as it was unique (as far as purchasing from peptide sources goes). Semaglutide-treated participants, compared with placebo, were also more likely to lose at least 10%, 15% or 20% of baseline body weight at week 104 (P < 0. Dosage: Oral. Not even sure it had anything in it. In January 2020, semaglutide was again approved to lower the likelihood of major adverse cardiovascular events in patients with Type 2 diabetes and is being marketed as Ozempic in this indication. We are a community that can openly discuss semaglutide compounds. He figured Semaglutide, again from peptide sciences, would help combat the hunger and serve as a useful tool to balance out any potential for insulin resistance attributed with MK677. This Semaglutide is awful. Everyone’s weight loss journey looks different and how much weight you have to lose will determine the duration of your program. Novo Nordisk holds a patent on the molecule, everyone else is selling it in violation of that patent. I have requested the testing they said they did and they have not replied. I don’t use Semaglutide but the sources are generally the same as I use for other. Arctic Peptides Semaglutide weight loss. SAF Research is one of many research peptide companies. The answer is patent protection, which is another way of saying government-granted monopoly. 27 mg = 10 units, and then incremented 54mg = 20 units, 1. 95, Priority or $49. Combined with training, diet, and perhaps Metformin, you can lose weight rapidly. 50mg/week in month two. I've tried two different vials and it just doesn't seem to have any effect with the exception of my stool being effected. I spent around $450 on 3 vials of Tirzepatide 10mg, having previously been on both Mounjaro and Peptide Sciences Tirzepatide and experienced almost immediate appetite suppression on both of them. Does anyone pre-fill a months worth of semaglutide injections (~4) and store in the fridge instead of filling an individual syringe every week? When researching, many compounding pharmacies send people home with a months worth of injections so I’m interested if this is a effective. Semaglutide Sellers and Syringe Storing. Dull-Net5464 • 8 mo. I purchased 5mg semaglutide from Artic Peptides. In January 2020, semaglutide was again approved to lower the likelihood of major adverse cardiovascular events in patients with Type 2 diabetes and is being marketed as Ozempic in this indication. It was developed to fight type 2 diabetes by lowering blood sugar levels, boosting insulin sensitivity, and reducing hunger. com published a piece Friday morning digging into the DIY weight loss craze that has people buying raw semaglutide from chemical manufacturing websites, mixing it at home with. We do not have a client named Elv Biolabs. 54K subscribers. When you have a monopoly you can charge what the market will bear, and it’ll apparently bear $1000 pens. While nearly 62% of patients achieved 10% or more. Arctic Peptides provides products strictly for research and development purposes. That’s helpful. BPC 157 helped me regain the ability to physically function after years of living with chronic issues including the inability to walk long distances. 2 comments. Are you noticing differences? Seems to work about the same at least at the lowest dose. I’m probably going to annoy some people asking this, but I see a lot of knowledgeable people on here. No one else had a problem, so I’m not sure why. Ordered semaglutide April 28th it Ordered semaglutide April 28th it arrived at my house today May 11th. I've tried two different vials and it just doesn't seem to have any effect with the exception of my stool being effected. 1 cln912 • 1 min. BPC 157 helped me regain the ability to physically function after years of living with chronic issues including the inability to walk long distances. . mdt xrs cz 457